Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.
J Transl Med. 2011 Jan 27;9 Suppl 1(Suppl 1):S4. doi: 10.1186/1479-5876-9-S1-S4.
Natural antibodies constitute a first-line of defence against pathogens; they may also play other roles in immune regulation and homeostasis, through their ability to bind host antigens, surface molecules and receptors. Natural anti-CCR5 antibodies can be decisive in preventing HIV infection in mucosal tissues and offer prompt and effective protection just at major sites of virus entry. Among natural anti-CCR5 antibodies, IgG and IgA to the ECL1 domain have been shown to block HIV effectively and durably without causing harm to the host. Their biological properties and their uncommon generation in subsets of HIV-infected and HIV-exposed individuals (so called ESN) will be introduced and discussed, with the aim at exploiting their potential in therapy and prevention.
天然抗体构成了抵抗病原体的第一道防线；通过结合宿主抗原、表面分子和受体的能力，它们还可能在免疫调节和稳态中发挥其他作用。天然抗 CCR5 抗体可以在黏膜组织中防止 HIV 感染方面发挥决定性作用，并在病毒进入的主要部位提供快速有效的保护。在天然抗 CCR5 抗体中，已证明针对 ECL1 结构域的 IgG 和 IgA 可以有效地、持久地阻断 HIV，而不会对宿主造成伤害。将介绍和讨论它们的生物学特性及其在 HIV 感染和 HIV 暴露个体（所谓的 ESN）亚群中的罕见产生，旨在利用它们在治疗和预防方面的潜力。
