Laboratory for Biomechanics and Biomaterials, Department of Orthopaedics, Hannover Medical School, Anna-von-Borries-Str. 1-7, 30625 Hannover, Germany.
Ann Biomed Eng. 2011 May;39(5):1546-54. doi: 10.1007/s10439-011-0257-x. Epub 2011 Feb 1.
Nitinol is a promising biomaterial based on its remarkable shape changing capacity, biocompatibility, and resilient mechanical properties. Until now, very limited applications have been tested for the use of Nitinol plates for fracture fixation in orthopaedics. Newly designed fracture-fixation plates are tested by four-point bending to examine a change in equivalent bending stiffness before and after shape transformation. The goal of stiffness alterable bone plates is to optimize the healing process during osteosynthesis in situ that is customized in time of onset, percent change as well as being performed non-invasively for the patient. The equivalent bending stiffness in plates of varying thicknesses changed before and after shape transformation in the range of 24-73% (p values <0.05 for all tests). Tests on a Nitinol plate of 3.0 mm increased in stiffness from 0.81 to 0.98 Nm² (corresponding standard deviation 0.08 and 0.05) and shared a good correlation to results from numerical calculation. The stiffness of the tested fracture-fixation plates can be altered in a consistent matter that would be predicted by determining the change of the cross-sectional area moment of inertia.
形状记忆合金是一种很有前途的生物材料，具有显著的形状记忆能力、生物相容性和弹性机械性能。到目前为止，只有非常有限的应用测试了使用形状记忆合金板进行骨科骨折固定。新设计的骨折固定板通过四点弯曲测试来检查形状变形前后等效弯曲刚度的变化。可调节刚度骨板的目标是优化原位骨合成过程中的愈合过程，该过程可根据发病时间、变化百分比以及对患者的非侵入性进行定制。不同厚度的板在形状变形前后的等效弯曲刚度变化范围为 24%-73%（所有测试的 p 值均<0.05）。对 3.0 毫米厚的形状记忆合金板进行的测试显示，其刚度从 0.81 增加到 0.98 Nm²（相应的标准偏差为 0.08 和 0.05），与数值计算结果相关性良好。通过确定横截面面积惯性矩的变化，可以以一致的方式改变测试用骨折固定板的刚度，这是可以预测的。
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