Division of Nuclear Medicine, Department of Radiology, St. Luke's-Roosevelt Hospital and Columbia University College of Physicians and Surgeons, New York, NY, USA.
J Nucl Cardiol. 2011 Apr;18(2):273-80. doi: 10.1007/s12350-011-9340-9. Epub 2011 Feb 2.
Wide Beam Reconstruction (WBR) (UltraSPECT, Ltd) uses resolution recovery and noise modeling to cope with decreased SPECT count statistics. Because WBR processing reconstructs half the usual SPECT count statistics, we postulate that image quality equivalent to a full-time acquisition can be achieved in either half the time or with half the radiopharmaceutical activity.
In 156 consecutive patients (pts) rest and 8-frame gated post-stress myocardial perfusion SPECT was performed following 333-444 and 1184-1480 MBq (9-12 and 32-40 mCi) Tc-99m sestamibi injections, respectively, with full-time (rest = 14 min; stress = 12.3 min) acquisitions processed with OSEM and also separate "half-time" acquisitions processed with WBR. A subsequent group of 160 consecutive pts matched in gender, weight, and chest circumference received "half-dose" rest and stress injections 214.6 ± 22.2 and 647.5 ± 92.5 MBq (5.8 ± 0.6 and 17.5 ± 2.5 mCi) with full-time SPECT acquisitions. Image quality (1 = poor to 5 = excellent) was judged by myocardial count density and uniformity, endocardial edge definition, perfusion defect delineation, right ventricular visualization, and background noise.
Mean image quality for rest, stress, and post-stress gated images were 3.6 ± 0.7, 3.8 ± 0.7, and 3.9 ± 1.0, respectively, for "full-time OSEM; 3.7 ± 0.8, 4.0 ± 0.7, and 4.8 ± 0.4 for "half-time" WBR; and 4.3 ± 0.8, 4.6 ± 0.6, and 4.7 ± 0.6 for "half-dose" WBR. "Half-time" and "half-dose" WBR image quality were both superior to standard full-time OSEM (P's < .001). There was no significant difference between the summed stress and rest scores for "full-time" OSEM vs "half-time" WBR in 82 patients with perfusion defects.
Both "half-time" and "half-dose" WBR provide myocardial perfusion SPECT quality superior to full-time OSEM, with an associated decrease in scan acquisition time and patient radiation exposure, respectively.
宽束重建（WBR）（UltraSPECT，Ltd）使用分辨率恢复和噪声建模来应对 SPECT 计数统计数据的减少。由于 WBR 处理重建了通常 SPECT 计数统计数据的一半，我们假设可以在一半的时间或一半的放射性药物活性内实现与全时间采集等效的图像质量。
在 156 例连续患者（pts）中，休息和 8 帧门控后应激心肌灌注 SPECT 分别在注射 333-444 和 1184-1480 MBq（9-12 和 32-40 mCi）Tc-99m sestamibi 后进行，使用全时间（休息=14 分钟；应激=12.3 分钟）采集，使用 OSEM 处理，也使用单独的“半时间”采集，使用 WBR 处理。随后，一组 160 例连续的患者在性别、体重和胸围方面相匹配，接受了 214.6±22.2 和 647.5±92.5 MBq（5.8±0.6 和 17.5±2.5 mCi）的“半剂量”休息和应激注射，并用全时间 SPECT 采集。通过心肌计数密度和均匀性、心内膜边缘定义、灌注缺损描绘、右心室可视化和背景噪声来判断图像质量（1=差到 5=优）。
休息、应激和后应激门控图像的平均图像质量分别为“全时间 OSEM”的 3.6±0.7、3.8±0.7 和 3.9±1.0；“半时间”WBR 的 3.7±0.8、4.0±0.7 和 4.8±0.4；以及“半剂量”WBR 的 4.3±0.8、4.6±0.6 和 4.7±0.6。“半时间”和“半剂量”WBR 的图像质量均优于标准全时间 OSEM（P<0.001）。在 82 例有灌注缺损的患者中，“全时间”OSEM 与“半时间”WBR 的总和应激和休息评分之间没有显著差异。
“半时间”和“半剂量”WBR 均提供优于全时间 OSEM 的心肌灌注 SPECT 质量，分别与扫描采集时间和患者辐射暴露减少相关。
