Biomedical Engineering and Technology Institute, Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, People's Republic of China.
Int J Nanomedicine. 2011 Jan 6;6:85-91. doi: 10.2147/IJN.S15839.
The purpose of this study was to develop a novel formulation of paclitaxel (PTX) that would improve its therapeutic index. Here, we combined a concept of polymer-PTX drug conjugate with a concept of polymeric micelle drug delivery to form novel free PTX-loaded poly(L-γ-glutamylglutamine) (PGG)-PTX conjugate nanoparticles. The significance of this drug formulation emphasizes the simplicity, novelty, and flexibility of the method of forming nanoparticles that contain free PTX and conjugated PTX in the same drug delivery system. The results of effectively inhibiting tumor growth in mouse models demonstrated the feasibility of the nanoparticle formulation. The versatility and potential of this dual PTX drug delivery system can be explored with different drugs for different indications. Novel and simple formulations of PTX-loaded PGG-PTX nanoparticles could have important implications in translational medicines.
本研究旨在开发一种新型紫杉醇（PTX）制剂，以提高其治疗指数。在这里，我们将聚合物-PTX 药物偶联物的概念与聚合物胶束药物递送的概念相结合，形成了新型游离 PTX 负载的聚（L-γ-谷氨酰-L-谷氨酰胺）（PGG）-PTX 结合纳米粒。这种药物制剂的意义在于强调了形成纳米粒的方法的简单性、新颖性和灵活性，该方法在同一药物递送系统中同时包含游离 PTX 和结合 PTX。在小鼠模型中有效抑制肿瘤生长的结果证明了该纳米粒制剂的可行性。这种双重 PTX 药物递送系统的多功能性和潜力可以通过不同的药物针对不同的适应症进行探索。载有 PTX 的 PGG-PTX 纳米粒的新型和简单制剂在转化医学中可能具有重要意义。
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