University of Connecticut Health Center, Division of Oral and Maxillofacial Surgery, School of Dental Medicine, Farmington, Connecticut, USA.
Ann N Y Acad Sci. 2011 Feb;1218:62-79. doi: 10.1111/j.1749-6632.2010.05835.x.
Bisphosphonates are used in the treatment of hypercalcemia of malignancy, skeletal complications associated with metastastic bone disease, Paget's disease, and osteoporosis. Osteonecrosis of the jaw (ONJ) is a recently described clinical condition that has been associated with the use of nitrogen-containing bisphosphonates. Reports describing this entity first appeared in the literature in 2003. While there have been significant numbers of case reports and a limited number of retrospective and prospective studies examining risk factors associated with ONJ, the pathophysiology of this condition remains elusive. In this review, we explore proposed mechanisms underlying ONJ development and identify potential areas for future investigation.
双膦酸盐用于治疗恶性高钙血症、转移性骨病相关的骨骼并发症、佩吉特病和骨质疏松症。颌骨坏死（ONJ）是一种新描述的临床病症，与使用含氮双膦酸盐有关。描述该病症的报告于 2003 年首次出现在文献中。虽然有大量的病例报告，以及有限数量的回顾性和前瞻性研究检查了与 ONJ 相关的危险因素，但该病症的病理生理学仍然难以捉摸。在这篇综述中，我们探讨了 ONJ 发展的潜在机制，并确定了未来研究的潜在领域。
