卵巢癌肉瘤中发生的恶性黑色素瘤：病例报告及文献复习。

Malignant melanoma arising in an ovarian carcinosarcoma: case report and review of the literature.

机构信息

Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA.

出版信息

Int J Gynecol Pathol. 2011 Mar;30(2):158-62. doi: 10.1097/PGP.0b013e3181f9eba5.

Abstract

A case of ovarian malignant mixed mullerian tumor (MMMT) with melanocytic differentiation is described. A 74-year-old woman presented with left lower quadrant pain. Pathologic examination of the left ovary revealed a MMMT, composed predominantly of serous carcinoma (90%) with a minor sarcoma component containing focal chondroid differentiation. There was also a single focus of malignant melanoma. Immunohistochemical studies showed that the latter was positive for S-100, HMB-45, and pan-melanoma cocktail, and was negative for synaptophysin and neuron-specific enolase. To the best of our knowledge, this is the first case of MMMT with melanocytic differentiation described in the ovary.

摘要

本文描述了一例卵巢恶性混合性苗勒管肿瘤（MMMT）伴黑色素细胞分化。一位 74 岁女性因左下腹疼痛就诊。左侧卵巢的病理检查显示 MMMT，主要由浆液性癌（90%）组成，伴有局灶性软骨分化的小肉瘤成分。还有一个恶性黑色素瘤的单一病灶。免疫组织化学研究表明，后者对 S-100、HMB-45 和泛黑色素瘤鸡尾酒呈阳性，对突触素和神经元特异性烯醇化酶呈阴性。据我们所知，这是首例卵巢恶性混合性苗勒管肿瘤伴黑色素细胞分化的病例。