Dow Chemical Company, Midland, MI 48674, USA.
J Occup Environ Med. 2011 Mar;53(3):239-44. doi: 10.1097/JOM.0b013e31820c90cf.
In 2004, The American Chemistry Council Phosgene Panel established a phosgene exposure registry among US phosgene producers with the primary purpose of monitoring health outcome information for workers with acute exposure.
We examine symptoms among 338 workers with phosgene exposure. The phosgene exposures averaged 8.3 ppm-minutes ranging up to 159 ppm-minutes with most exposures below 10 ppm-minutes.
We found that the level of phosgene exposure in ppm-minutes was related to workers reporting mostly irritation symptoms of the nose, throat and eyes within 48 hours of exposure. However, we found no relationship between phosgene exposure and the presence of symptoms 30 days after exposure.
These findings lend credence to the theory that prolonged respiratory effects do not occur with doses less than 150 ppm-minutes.
2004 年，美国化学理事会光气小组在美国光气生产商中建立了光气暴露登记处，主要目的是监测急性暴露工人的健康结果信息。
我们检查了 338 名接触光气工人的症状。光气暴露的平均浓度为 8.3ppm 分钟，最高可达 159ppm 分钟，大多数暴露低于 10ppm 分钟。
我们发现，ppm 分钟的光气暴露水平与工人在暴露后 48 小时内报告的主要是鼻子、喉咙和眼睛刺激症状有关。然而，我们没有发现光气暴露与暴露 30 天后出现症状之间存在关系。
这些发现为剂量小于 150ppm 分钟不会引起长期呼吸道影响的理论提供了依据。
