Department of Molecular Enzymology, Kumamoto University Faculty of Life Sciences, Honjo, Kumamoto 860-8556, Japan.
Dev Comp Immunol. 2011 Jul;35(7):705-15. doi: 10.1016/j.dci.2011.01.019. Epub 2011 Feb 2.
Chemokines receptors are involved in the recruitment of various cell types in inflammatory and physiological conditions. There are 23 known chemokine receptor genes in the human genome. However, it is still unclear how many chemokine receptors exist in the genomes of various vertebrate species other than human and mouse. Moreover, the orthologous relationships are often obscure between the genes of higher and lower vertebrates. In order to provide a basis for a unified nomenclature system of the vertebrate chemokine receptor gene family, we have analysed the chemokine receptor genes from the genomes of 16 vertebrate species, and classify them into 29 orthologous groups using phylogenetic and comparative genomic analyses. The results reveal a continuous gene birth and death process during the vertebrate evolution and an interesting evolutionary history of the chemokine receptor genes after the emergence in agnathans.
趋化因子受体参与炎症和生理条件下各种细胞类型的募集。人类基因组中有 23 个已知的趋化因子受体基因。然而，在人类和小鼠以外的各种脊椎动物基因组中，究竟存在多少种趋化因子受体仍然不清楚。此外，高等脊椎动物和低等脊椎动物的基因之间的同源关系往往不明显。为了为脊椎动物趋化因子受体基因家族的统一命名系统提供依据，我们分析了来自 16 种脊椎动物基因组的趋化因子受体基因，并使用系统发育和比较基因组学分析将它们分为 29 个同源群。结果表明，在脊椎动物进化过程中存在连续的基因诞生和消亡过程，以及在无颌类出现后趋化因子受体基因的有趣进化历史。
