细胞命运的扭转。

A twist of cell fate.

机构信息

University of California-San Francisco, CA 94143-0506, USA.

出版信息

Cell Stem Cell. 2011 Feb 4;8(2):126-7. doi: 10.1016/j.stem.2011.01.004.

DOI:10.1016/j.stem.2011.01.004

Abstract

Individuals carrying deleterious BRCA1 mutations typically develop basal-like rather than luminal breast cancers. In this issue of Cell Stem Cell, Proia et al. (2011) study breast tissue from women with heterozygous BRCA1 mutations and identify molecular mechanisms that regulate mammary progenitor cell differentiation and bias toward subsequent basal-like tumor formation.

摘要

携带有害 BRCA1 突变的个体通常会发展为基底样而非腔面乳腺癌。在本期《Cell Stem Cell》中，Proia 等人（2011）研究了携带杂合 BRCA1 突变的女性的乳腺组织，并确定了调节乳腺祖细胞分化和偏向随后基底样肿瘤形成的分子机制。