Dasari Tarun W, Pappy Reji, Hennebry Thomas A
920 Stanton L. Young Blvd., WP 3010, Cardiovascular Section, OUHSC, Oklahoma City, OK 73190, USA.
J Invasive Cardiol. 2011 Feb;23(2):E5-8.
Heparin-induced thrombocytopenia (HIT) is a wellknown complication after exposure to heparin products. Profound thrombocytopenia has also been reported with the use of abciximab, a glycoprotein IIb/IIIa receptor antagonist, which is used during percutaneous coronary intervention. Acute stent thrombosis is a rare but serious complication of HIT. We report an unusual case of acute stent thrombosis with concomitant heparin- and abciximab-induced profound thrombocytopenia and discuss the subsequent treatment strategies. Prompt identification and management of this disorder is critically important to avoid devastating complications.
肝素诱导的血小板减少症（HIT）是接触肝素产品后一种众所周知的并发症。使用阿昔单抗（一种糖蛋白IIb/IIIa受体拮抗剂，用于经皮冠状动脉介入治疗期间）也有严重血小板减少症的报道。急性支架血栓形成是HIT一种罕见但严重的并发症。我们报告了一例伴有肝素和阿昔单抗诱导的严重血小板减少症的急性支架血栓形成的罕见病例，并讨论了后续的治疗策略。迅速识别和处理这种疾病对于避免毁灭性并发症至关重要。
