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临床和实验证据表明,氧化应激是糖尿病恶化的一个因素。

Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus.

机构信息

Department of Internal Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

出版信息

J Clin Biochem Nutr. 2011 Jan;48(1):72-7. doi: 10.3164/jcbn.11-014FR. Epub 2010 Dec 28.

Abstract

The involvement of reactive oxygen species in various diseases has been demonstrated almost in vitro or in animal studies and clinical studies supporting the involvement of reactive oxygen species are very few. Bilirubin has been recognized as an important antioxidant and also shown to have an inhibitory effect on the activity of NADPH oxidase, which may be an important source for superoxide production in various tissues. When the prevalence of vascular complcations was compared in diabetic patients with and without a congenital hyperbilirubinemia (Gilbert syndrome), the prevalence of retinopathy, macroalbuminuria and coronary artery disease in patients with Gilbert syndrome was about 20% of that in those without Gilbert syndrome. For study of lifestyle-related diseases, the Fukuoka Cohort was constructed from 2003 to 2009 in Kyushu area in Japan, which contains a total of 12,949 persons. Cross-sectional study of the Fukuoka Cohort revealed an inverse relation between serum bilirubin level and the prevalence of type 2 diabetes mellitus. A precursor of bilirubin, biliverdin-treated db/db mice exhibited less albuminuria and nephropathic changes. These effects were paralleled with normalization of oxidative stress markers and expression of NAD(P)H oxidase subunits in kidney. These results suggested that oxidative stress is an exacerbating factor of type 2 diabetes mellitus and that antioxidant therapies are of value to diabetic nephropathy.

摘要

活性氧物种在各种疾病中的作用已在体外或动物研究中得到证实,而支持活性氧物种参与的临床研究却很少。胆红素已被认为是一种重要的抗氧化剂,并且还显示出对 NADPH 氧化酶活性的抑制作用,NADPH 氧化酶可能是各种组织中超氧产生的重要来源。当比较伴有和不伴有先天性高胆红素血症(吉尔伯特综合征)的糖尿病患者中血管并发症的患病率时,吉尔伯特综合征患者的视网膜病变、大量白蛋白尿和冠心病的患病率约为无吉尔伯特综合征患者的 20%。为了研究与生活方式相关的疾病,日本九州地区于 2003 年至 2009 年构建了福冈队列,其中共包含 12949 人。福冈队列的横断面研究显示,血清胆红素水平与 2 型糖尿病的患病率呈负相关。胆红素的前体——胆红素处理的 db/db 小鼠表现出较少的蛋白尿和肾病变化。这些作用与氧化应激标志物和肾脏中 NAD(P)H 氧化酶亚基表达的正常化平行。这些结果表明,氧化应激是 2 型糖尿病的加重因素,抗氧化治疗对糖尿病肾病有价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e91e/3022068/77ad44c13817/jcbn11-014FRf01.jpg

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