BDNF 基因敲除海马体通过上调 5-HT3 受体减弱 CA1 区的γ振荡。
Hippocampal deletion of BDNF gene attenuates gamma oscillations in area CA1 by up-regulating 5-HT3 receptor.
机构信息
Unit on Behavioral Genetics, Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America.
出版信息
PLoS One. 2011 Jan 26;6(1):e16480. doi: 10.1371/journal.pone.0016480.
BACKGROUND
Pyramidal neurons in the hippocampal area CA3 express high levels of BDNF, but how this BDNF contributes to oscillatory properties of hippocampus is unknown.
METHODOLOGY/PRINCIPAL FINDINGS: Here we examined carbachol-induced gamma oscillations in hippocampal slices lacking BDNF gene in the area CA3. The power of oscillations was reduced in the hippocampal area CA1, which coincided with increases in the expression and activity of 5-HT3 receptor. Pharmacological block of this receptor partially restored power of gamma oscillations in slices from KO mice, but had no effect in slices from WT mice.
CONCLUSION/SIGNIFICANCE: These data suggest that BDNF facilitates gamma oscillations in the hippocampus by attenuating signaling through 5-HT3 receptor. Thus, BDNF modulates hippocampal oscillations through serotonergic system.
背景
海马区 CA3 中的锥体神经元表达高水平的 BDNF，但这种 BDNF 如何影响海马的振荡特性尚不清楚。
方法/主要发现：在这里，我们检查了在 CA3 区缺乏 BDNF 基因的海马切片中，由 carbachol 诱导的γ振荡。在海马 CA1 区的振荡功率降低，同时 5-HT3 受体的表达和活性增加。该受体的药理学阻断部分恢复了 KO 小鼠切片中的γ振荡功率，但对 WT 小鼠切片没有影响。
结论/意义：这些数据表明，BDNF 通过减弱 5-HT3 受体的信号传递来促进海马中的γ振荡。因此，BDNF 通过 5-羟色胺能系统调节海马的振荡。
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