Tishyadhigama Prapawadee, Dejsirilert Surang, Thongmali Orathai, Sawanpanyalert Pathom, Aswapokee Nalinee, Piboonbanakit Dadanabhand
National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand.
J Med Assoc Thai. 2009 Aug;92 Suppl 4:S8-18.
From 2000 to 2005, the data of all clinical isolates of Staphylococcus aureus including methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) from 28 hospitals in the National Antimicrobial Resistance Surveillance, Thailand (NARST) program were reviewed and analyzed for the prevalence and pattern of antimicrobial susceptibility by WHONET software program. Among all isolates, around 26% of MRSA have been noted in each year The rates of erythromycin-resistant MRSA were relatively high, ranging from 94.5% to 96.8%, followed by clindamycin resistant (37.4% to 68.9%), fosfomycin-resistant (7.7% to 17%), vancomycin-resistant (0.1% to 0.8%), and teicoplanin resistant (0.2% to 1.3%). The rates of antimicrobial resistance MSSA were constantly low, with erythromycin resistance ranging from 3.7% to 4.6%, clindamycin resistance ranging from 1.4% to 2.3%, fosfomycin resistance ranging from 0.7% to 1.4%, vancomycin resistance ranging from 0.1% to 1.2%, and teicoplanin resistance ranging from 0.1% to 1.1%. An increasing trend of vancomycin resistance in S. aureus determined by the disk diffusion method should be further confirmed by appropriate susceptibility methods. Molecular typing methods are needed to determine the epidemiological association between these resistant isolates.
2000年至2005年，对泰国国家抗菌药物耐药性监测（NARST）项目中28家医院的所有金黄色葡萄球菌临床分离株数据进行了回顾和分析，这些分离株包括甲氧西林敏感金黄色葡萄球菌（MSSA）和甲氧西林耐药金黄色葡萄球菌（MRSA），采用WHONET软件程序分析抗菌药物敏感性的流行情况和模式。在所有分离株中，每年约有26%为MRSA。耐红霉素的MRSA比例相对较高，在94.5%至96.8%之间，其次是耐克林霉素（37.4%至68.9%）、耐磷霉素（7.7%至17%）、耐万古霉素（0.1%至0.8%）和耐替考拉宁（0.2%至1.3%）。MSSA的抗菌药物耐药率一直较低，耐红霉素率在3.7%至4.6%之间，耐克林霉素率在1.4%至2.3%之间，耐磷霉素率在0.7%至1.4%之间，耐万古霉素率在0.1%至1.2%之间，耐替考拉宁率在0.1%至1.1%之间。通过纸片扩散法测定的金黄色葡萄球菌对万古霉素耐药性的上升趋势应通过适当的药敏方法进一步确认。需要采用分子分型方法来确定这些耐药分离株之间的流行病学关联。
