Centre d'imagerie moléculaire de Sherbrooke (CIMS), Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Québec, Canada J1H 5N4.
J Org Chem. 2011 Mar 18;76(6):1887-90. doi: 10.1021/jo102083g. Epub 2011 Feb 8.
Phthalocyanines (Pc) were conjugated with peptide moieties to improve their target selectivity for potential use as fluorescence and/or positron emission tomography (PET) probes in medical imaging. Three synthetic methods based on palladium-catalyzed cross-coupling reactions (Sonogashira, Buchwald-Hartwig, and Suzuki-Miyaura) were investigated. Using these methods, a series of peptides monofunctionalized with Pc at the N/C-terminal position or on a phenylalanine side chain was obtained in good yields and characterized.
酞菁（Pc）与肽片段缀合，以提高其对潜在作为荧光和/或正电子发射断层扫描（PET）探针在医学成像中的目标选择性。研究了三种基于钯催化交叉偶联反应（Sonogashira、Buchwald-Hartwig 和 Suzuki-Miyaura）的合成方法。使用这些方法，可以以良好的收率获得一系列在 N/C 末端位置或苯丙氨酸侧链上单官能化的 Pc 肽，并对其进行了表征。
