磺胺嘧啶锌对大鼠的抗胃溃疡活性

[Anti-gastric ulcer activity of zinc sulfadiazine in rats].

作者信息

Gu G G, Yong D G, Geng B Q

机构信息

Department of Pharmacology, Zhejiang Medical University, Hangzhou, China.

出版信息

Zhongguo Yao Li Xue Bao. 1990 Sep;11(5):460-2.

PMID:2130605

Abstract

Zinc sulfadiazine (ZnSD) 50, 100, 200 mg/kg ig inhibited the formation of gastric ulcer induced by indomethacin, stress and pyloric ligation in rats respectively and showed dose-dependently. ZnSD 200 mg/kg ig accelerated the healing of gastric ulcer induced by acetic acid. ZnSD 25 mg/kg ig was effective in preventing ethanol-induced damage of rat gastric mucosa. The amount of gastric mucus glycoprotein in gastric tissues was increased by ZnSD. In general, ZnSD did not influence the volume of gastric juice and pepsin output, but ZnSD 200 mg/kg ig decreased gastric acidity. In vitro, ZnSD also influenced the neutralization of acid. It is suggested that antiulcer action of ZnSD may be related to its preservation of the gastric mucosal barrier and neutralization of acid.

摘要

磺胺嘧啶锌（ZnSD）分别以50、100、200mg/kg的剂量灌胃给药，可抑制吲哚美辛、应激和幽门结扎诱导的大鼠胃溃疡形成，且呈剂量依赖性。ZnSD 200mg/kg灌胃给药可加速乙酸诱导的大鼠胃溃疡愈合。ZnSD 25mg/kg灌胃给药可有效预防乙醇诱导的大鼠胃黏膜损伤。ZnSD可增加胃组织中胃黏液糖蛋白的含量。总体而言，ZnSD不影响胃液分泌量和胃蛋白酶分泌量，但ZnSD 200mg/kg灌胃给药可降低胃酸度。在体外，ZnSD也可影响酸的中和。提示ZnSD的抗溃疡作用可能与其保护胃黏膜屏障和中和胃酸有关。