State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, PO Box 261, Beijing 100191, China.
Chem Biol Drug Des. 2011 Mar;77(3):189-98. doi: 10.1111/j.1747-0285.2010.01050.x.
N-acylhydrazones containing glycine residue 3a-j and 8a-h were synthesized as HIV-1 capsid protein assembly inhibitors. The structures of the novel N-acylhydrazone derivatives were characterized using different spectroscopic methods. Antiviral activity demonstrated that compound 8c bearing 4-methylphenyl moiety was the most active with low cytotoxicity.
含有甘氨酸残基 3a-j 和 8a-h 的 N-酰腙类化合物被合成为 HIV-1 衣壳蛋白组装抑制剂。新型 N-酰腙衍生物的结构通过不同的光谱方法进行了表征。抗病毒活性表明，带有 4-甲基苯基部分的化合物 8c 具有最低的细胞毒性和最高的活性。
