含甘氨酸残基的新型 N-酰腙的合成及抗病毒活性评价。
Synthesis and antiviral evaluation of new N-acylhydrazones containing glycine residue.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, PO Box 261, Beijing 100191, China.
出版信息
Chem Biol Drug Des. 2011 Mar;77(3):189-98. doi: 10.1111/j.1747-0285.2010.01050.x.
Abstract
N-acylhydrazones containing glycine residue 3a-j and 8a-h were synthesized as HIV-1 capsid protein assembly inhibitors. The structures of the novel N-acylhydrazone derivatives were characterized using different spectroscopic methods. Antiviral activity demonstrated that compound 8c bearing 4-methylphenyl moiety was the most active with low cytotoxicity.
摘要
含有甘氨酸残基 3a-j 和 8a-h 的 N-酰腙类化合物被合成为 HIV-1 衣壳蛋白组装抑制剂。新型 N-酰腙衍生物的结构通过不同的光谱方法进行了表征。抗病毒活性表明，带有 4-甲基苯基部分的化合物 8c 具有最低的细胞毒性和最高的活性。
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