Wu Yu-Qi, Shan Hong-Wei, Zhao Xian-Yu, Yang Xing-Yi
The First People's Hospital, Yichang 443002, Hubei, China.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011 Feb;23(2):88-90.
To investigate the risk factors of nosocomial infection caused by Pseudomonas aeruginosa in intensive care unit (ICU), in order to provide reference for an effective measure of infection control.
A retrospective study of cases of Pseudomonas aeruginosa infection occurring in ICU was made with multivariable Logistic regression analysis. The clinical data of 1 950 cases admitted from January 2002 to December 2006 were found to have nosocomial infection caused by Pseudomonas aeruginosa were analyzed in order to identify its independent risk factors.
Sixty-four out of 1 950 patients were found to suffer from nosocomial infection caused by Pseudomonas aeruginosa, the morbidity rate was 3.3%. At the same time, and in the same department, 37 patients suffering from infection caused by Escherichia coli, served as control group. Univariate analysis showed that the risk factors for nosocomial infection caused by Pseudomonas aeruginosa were the use of corticosteroid, unconsciousness or craniocerebral trauma, abdominal surgery, thorax/abdomen drainage tube, mechanical ventilation, and tracheostomy [the use of corticosteroid: odds ratio (OR)=3.364, 95% confidence interval (95%CI) 1.445-7.830; unconsciousness or craniocerebral trauma: OR=4.026, 95%CI 1.545-10.490; abdominal surgery: OR=0.166, 95%CI 0.068-0.403; thorax/abdomen drainage tube: OR=0.350, 95%CI 0.150-0.818; tracheostomy: OR=4.095, 95%CI 1.638-10.740]. Multivariate analysis showed that the independent risk factors of nosocomial infection caused by Pseudomonas aeruginosa in ICU were: the use of corticosteroid and mechanical ventilation [the use of corticosteroid: OR=3.143, 95%CI 1.115-8.856; mechanical ventilation: OR=3.195, 95%CI 1.607-6.353, P<0.05 and P<0.01].
The independent risk factors of nosocomial infection caused by Pseudomonas aeruginosa in ICU are the use of corticosteroid and mechanical ventilation. Measures should be taken to take care of the risk factors in order to prevent nosocomial infection caused by Pseudomonas aeruginosa in ICU.
探讨重症监护病房（ICU）铜绿假单胞菌医院感染的危险因素，为采取有效的感染控制措施提供参考。
对ICU发生的铜绿假单胞菌感染病例进行回顾性研究，并进行多变量Logistic回归分析。分析2002年1月至2006年12月收治的1950例发生铜绿假单胞菌医院感染患者的临床资料，以确定其独立危险因素。
1950例患者中64例发生铜绿假单胞菌医院感染，发病率为3.3%。同时，选取同一科室37例大肠埃希菌感染患者作为对照组。单因素分析显示，铜绿假单胞菌医院感染的危险因素为使用糖皮质激素、意识不清或颅脑外伤、腹部手术、胸/腹腔引流管、机械通气及气管切开术[使用糖皮质激素：比值比（OR）=3.364，95%可信区间（95%CI）1.445 - 7.830；意识不清或颅脑外伤：OR = 4.026，95%CI 1.545 - 10.490；腹部手术：OR = 0.166，95%CI 0.068 - 0.403；胸/腹腔引流管：OR = 0.350，95%CI 0.150 - 0.818；气管切开术：OR = 4.095，95%CI 1.638 - 10.740]。多因素分析显示，ICU铜绿假单胞菌医院感染的独立危险因素为使用糖皮质激素和机械通气[使用糖皮质激素：OR = 3.143，95%CI 1.115 - 8.856；机械通气：OR = 3.195，95%CI 1.607 - 6.353，P < 0.05和P < 0.01]。
ICU铜绿假单胞菌医院感染的独立危险因素为使用糖皮质激素和机械通气。应针对这些危险因素采取措施，以预防ICU铜绿假单胞菌医院感染。
