Division of Hematology/Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA.
Cancers (Basel). 2011 Jan 1;3(1):319-39. doi: 10.3390/cancers3010319.
Colorectal cancer is the third-leading cause of cancer related mortality in the United States. The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. In parallel with this, experiment evidence has emerged supporting the century old hypothesis that solid tumor initiation, progression, chemoresistance and recurrence is the result of a small population of cancer cells with self-renewal and pluripotency capabilities. These "cancer stem cells" (CSCs) present a unique opportunity to better understand the biology of solid tumors in general, as well as targets for future therapeutics. In this review, we will summarize the current understanding of intestinal stem cell biology and translate it to colorectal CSCs to provide a basis for understanding chemoresistance, cancer recurrence and metastasis. A more complete understanding of the biology of colorectal CSCs will translate into the development of better chemotherapeutic and biological agents for the treatment of colorectal cancer.
结直肠癌是美国癌症相关死亡的第三大主要原因。正常肠道再生过程中涉及的复杂分子机制和假定的体干细胞的身份已经变得清晰。与此平行的是，实验证据支持了一个世纪前的假说，即实体肿瘤的起始、进展、化疗耐药和复发是一小部分具有自我更新和多能性能力的癌细胞的结果。这些“癌症干细胞”（CSC）为更好地了解一般实体肿瘤的生物学以及未来治疗的靶点提供了独特的机会。在这篇综述中，我们将总结目前对肠干细胞生物学的理解，并将其转化为结直肠 CSC，为理解化疗耐药、癌症复发和转移提供基础。对结直肠 CSC 生物学的更全面理解将转化为更好的化疗和生物制剂的开发，用于治疗结直肠癌。
Zotero 插件
