Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Autophagy. 2011 May;7(5):544-6. doi: 10.4161/auto.7.5.15056. Epub 2011 May 1.
Autophagy, an intracellular degradation pathway involved in cell survival or demise, is tightly controlled by complex regulatory mechanisms. A link between the Rb tumor suppressor and autophagy is now emerging. pRb plays a critical role in cell cycle progression and survival as well as the differentiation of certain cell types. Recently, we have reported that during skeletal myogenesis, Rb-deficient myoblasts fuse to form short myotubes that quickly degenerate. Myotube degeneration was associated with increased autophagic flux and inhibition of autophagy rescued the defect leading to long, twitching myotubes. We propose that Rb-loss sensitizes cells to autophagy via direct and indirect mechanisms and we discuss how these might affect cancer progression and response to chemotherapy.
自噬是一种参与细胞存活或死亡的细胞内降解途径，受到复杂的调控机制的严格控制。Rb 肿瘤抑制因子与自噬之间的联系正在浮现。pRb 在细胞周期进展和存活以及某些细胞类型的分化中起着关键作用。最近，我们报道在骨骼肌发生过程中，Rb 缺陷的成肌细胞融合形成短肌管，这些肌管很快退化。肌管退化与自噬通量增加有关，抑制自噬可挽救缺陷，导致长而抽搐的肌管。我们提出 Rb 缺失通过直接和间接机制使细胞对自噬敏感，我们讨论了这些机制如何影响癌症的进展和对化疗的反应。
