Division of Medical Oncology and Hematology, Princess Margaret Hospital, and Department of Medicine, University of Toronto, Toronto, ON.
Curr Oncol. 2011 Jan;18(1):e9-e18. doi: 10.3747/co.v18i1.623.
The identification of numerous breast cancer antigens has generated increasing enthusiasm for the application of immune-based therapies in breast malignancies. Although the use of monoclonal antibodies has revolutionized the "targeted therapy" of breast cancer, and the immunomodulatory effects of bisphosphonates continue to be evaluated, few studies to date have demonstrated widespread utility for other forms of immunotherapy. The present review assesses modern research and explores whether the hopes for immunotherapy can overcome the hype.
已经鉴定出许多乳腺癌抗原，这使得人们对免疫疗法在乳腺癌中的应用产生了浓厚的兴趣。尽管单克隆抗体的应用已经彻底改变了乳腺癌的“靶向治疗”，并且双磷酸盐的免疫调节作用仍在不断评估中，但迄今为止，很少有研究表明其他形式的免疫疗法具有广泛的应用价值。本文综述了现代研究，并探讨了免疫疗法的希望是否能够克服炒作。
