Università degli Studi dell'Insubria, Dipartimento di Scienze Chimiche e Ambientali, Via Valleggio 11, I-22100, Como, Italy.
Dalton Trans. 2011 May 7;40(17):4355-73. doi: 10.1039/c0dt01517b. Epub 2011 Feb 17.
The use of non covalent supramolecular ligand-ligand and ligand-substrate interactions in transition metal-catalysed transformations is a new, rapidly emerging area of research. Non-covalent interactions between monodentate ligands such as hydrogen bonding, coordinative bonding, ion pairing, π-π interactions and the formation of inclusion compounds, have been shown to impart higher activity and chemo-, regio-, and stereoselectivity to the corresponding transition metal complexes in a number of catalytic applications. Analogously, supramolecular ligand-substrate interactions, and particularly hydrogen bonding, have been used to direct the regio- and stereochemistry of several metal-catalysed reactions. The catalytic systems relying on supramolecular interactions are generally capable of self-assembling from simpler components in the environment where catalysis is to take place, and are therefore very well-suited for combinatorial catalyst discovery strategies and high-throughput screening.
在过渡金属催化转化中使用非共价超分子配体-配体和配体-底物相互作用是一个新的、迅速发展的研究领域。已经证明，氢键、配位键、离子对、π-π 相互作用和包合物的形成等单价配体之间的非共价相互作用，可以在许多催化应用中赋予相应的过渡金属配合物更高的活性和化学选择性、区域选择性和立体选择性。类似地，超分子配体-底物相互作用，特别是氢键，已被用于指导几种金属催化反应的区域和立体化学。依赖于超分子相互作用的催化体系通常能够从环境中更简单的催化反应组分中自组装，因此非常适合组合催化剂发现策略和高通量筛选。
