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新生儿卡介苗接种的抗哮喘作用不依赖于 Th17/Th1 而是 BALB/c 小鼠哮喘模型中的 IL-17/IFN-γ 平衡。

The antiasthma effect of neonatal BCG vaccination does not depend on the Th17/Th1 but IL-17/IFN-γ balance in a BALB/c mouse asthma model.

机构信息

Department of Respiratory Medicine, Children's Hospital, Chongqing Medical University, Chongqing, 400014, People's Republic of China.

出版信息

J Clin Immunol. 2011 Jun;31(3):419-29. doi: 10.1007/s10875-010-9503-5. Epub 2011 Feb 22.

DOI:10.1007/s10875-010-9503-5
PMID:21340706
Abstract

OBJECTIVE: This study aimed to determine whether the protective effects of the Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccination on allergic asthma are associated with the T helper (Th) 17/Th1 balance in a murine asthma model. METHODS: BALB/c neonates were vaccinated with BCG on the first day after birth, sensitized with ovalbumin, and then challenged with allergen. The resulting airway inflammation and responsiveness were measured. The levels of IL-17 and interferon (IFN)-γ in BALF and ratio of Th17/Th1 were investigated. RESULTS: We found that although BCG neonatal vaccination inhibited airway hyperresponsiveness and inflammation following allergen challenge in a BALB/c mouse asthma model, reduced levels of Th2 cytokines were not observed. However, BCG neonatal vaccination reduced IL-17 production and increased IFN-γ production in both the bronchoalveolar lavage fluid and the lung lymphocytes in asthmatic mice. CONCLUSION: The antiasthma effects of neonatal BCG vaccination reversed the IL-17/IFN-γ imbalance in a murine asthma model but did not depend on modifying the Th17/Th1 balance.

摘要

目的：本研究旨在探讨卡介苗（BCG）接种对变应性哮喘的保护作用是否与哮喘小鼠模型中辅助性 T 细胞（Th）17/Th1 平衡有关。

方法：新生 BALB/c 小鼠于出生后第 1 天接种 BCG，用卵清蛋白致敏，然后用变应原攻击。测量由此产生的气道炎症和反应性。检测 BALF 中 IL-17 和干扰素（IFN）-γ水平及 Th17/Th1 比值。

结果：我们发现，尽管 BCG 新生儿接种可抑制 BALB/c 哮喘小鼠模型中变应原攻击后的气道高反应性和炎症，但并未观察到 Th2 细胞因子水平降低。然而，BCG 新生儿接种可减少哮喘小鼠支气管肺泡灌洗液和肺淋巴细胞中 IL-17 的产生，增加 IFN-γ 的产生。

结论：新生儿 BCG 接种的抗哮喘作用可逆转哮喘小鼠模型中 IL-17/IFN-γ 失衡，但不依赖于调节 Th17/Th1 平衡。

相似文献

[1]
The antiasthma effect of neonatal BCG vaccination does not depend on the Th17/Th1 but IL-17/IFN-γ balance in a BALB/c mouse asthma model.

J Clin Immunol. 2011-2-22

[2]
[Combined effects of neonatal Bacillus Calmette-Guerin vaccination and respiratory syncytial infection on experimental asthma in mice].

Zhonghua Er Ke Za Zhi. 2006-6

[3]
Inhibition of IFN-γ promotes anti-asthma effect of Mycobacterium bovis Bacillus Calmette-Guerin neonatal vaccination: a murine asthma model.

Vaccine. 2014-2-22

[4]
Protective effects of combined Mycobacterium bovis BCG and interleukin-12 vaccination on airway inflammation in a murine model of allergic asthma.

Clin Invest Med. 2010-6-1

[5]
[Impact of neonatal bacillus Calmette-Guerin vaccination on lung Th17 cells and IL-17 in murine asthma model].

Zhongguo Dang Dai Er Ke Za Zhi. 2010-8

[6]
Inoculation route-dependent and allergen-specific suppressive effects of bacille Calmette-Guérin vaccination on asthmatic reactions in BALB/c mice.

Lung. 2007

[7]
Neonatal vaccination with Bacillus Calmette-Guérin elicits long-term protection in mouse-allergic responses.

Allergy. 2008-5

[8]
Th2 responses in OVA-sensitized BALB/c mice are down-modulated by Mycobacterium bovis BCG treatment.

J Clin Immunol. 2012-8-4

[9]
Blockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection.

J Immunol. 2012-9-12

[10]
Inhibition of allergen-induced airway remodeling by neonatal bacillus Calmette-Guerin vaccination is associated with interferon-gamma-producing T cells but not regulatory T cells in mice.

Ann Allergy Asthma Immunol. 2011-6-15

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[3]
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[5]
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[6]
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Front Immunol. 2021

[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in mice.

J Immunol. 2010-12-6

[2]
A new look at the pathogenesis of asthma.

Clin Sci (Lond). 2009-12-23

[3]
Does BCG vaccination protect against the development of childhood asthma? A systematic review and meta-analysis of epidemiological studies.

Int J Epidemiol. 2009-10-12

[4]
Development of allergen-induced airway inflammation in the absence of T-bet regulation is dependent on IL-17.

J Immunol. 2009-10-15

[5]
Intrinsic asthma: not so different from allergic asthma but driven by superantigens?

Clin Exp Allergy. 2009-8

[6]
BCG priming of dendritic cells enhances T regulatory and Th1 function and suppresses allergen-induced Th2 function in vitro and in vivo.

Int Arch Allergy Immunol. 2009

[7]
Interleukin-17A mediates acquired immunity to pneumococcal colonization.

PLoS Pathog. 2008-9-19

[8]
Neonatal vaccination with Bacillus Calmette-Guérin elicits long-term protection in mouse-allergic responses.

Allergy. 2008-5

[9]
TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA.

J Allergy Clin Immunol. 2007-10

[10]
Evaluation of BCG administration as an adjuvant to specific immunotherapy in asthmatic children with mite allergy.

J Allergy Clin Immunol. 2007-7

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