Maroto Luis C, Carnero Manuel, Silva Jacobo A, Cobiella Javier, Pérez-Castellano Nicasio, Reguillo Fernando, Pérez-Villacastín Julián, Rodríguez José E
Department of Cardiac Surgery, Cardiovascular Institute, Hospital Clínico San Carlos, 28040 Madrid, Spain.
Interact Cardiovasc Thorac Surg. 2011 May;12(5):681-6. doi: 10.1510/icvts.2010.261842. Epub 2011 Feb 22.
We sought to determine if early recurrence of atrial fibrillation (AF) after surgical ablation is a risk factor of late failure. Between February 2004 to May 2009, 106 patients underwent surgical ablation of concomitant permanent AF with radiofrequency. Operations primarily consisted of valve surgery in 85% of patients. Hospital mortality was 2.8% (n = 3). The median follow-up was 37 months (interquartile rank 12-77), and was complete in 99% of patients. Freedom from AF was 82%, 76% and 68% at one, two and three years, respectively. Patients with early recurrence of AF had less prevalence of sinus rhythm in late follow-up (P < 0.001). Multivariate Cox regression analysis showed that AF duration [hazard ratio (HR) 1.014, 95% CI 1.009-1.020, P < 0.001] and early recurrence of AF (HR 3.45, 95% CI 1.50-7.95, P = 0.004) were independent risk factors for failure. In conclusion, in our series, early recurrence of AF after surgical ablation is a strong predictor of late failure.
我们试图确定手术消融后房颤(AF)的早期复发是否为晚期治疗失败的危险因素。在2004年2月至2009年5月期间,106例患者接受了射频消融治疗永久性房颤。85%的患者主要接受瓣膜手术。医院死亡率为2.8%(n = 3)。中位随访时间为37个月(四分位间距12 - 77),99%的患者随访完整。术后1年、2年和3年无房颤的比例分别为82%、76%和68%。房颤早期复发的患者在晚期随访中窦性心律的发生率较低(P < 0.001)。多因素Cox回归分析显示,房颤持续时间[风险比(HR)1.014,95%可信区间1.009 - 1.020,P < 0.001]和房颤早期复发(HR 3.45,95%可信区间1.50 - 7.95,P = 0.004)是治疗失败的独立危险因素。总之,在我们的研究系列中,手术消融后房颤的早期复发是晚期治疗失败的有力预测指标。