Logothetou-Rella H, Nesland J M, Kipiotis D, Paraschou E, Sechas M, Varonos D D
Department of Experimental Physiology, University of Athens, Medical School, Greece.
Histol Histopathol. 1990 Jan;5(1):55-64.
Microvascular endothelial cells derived from canine subcutaneous adipose tissue formed knob-like and tube-like structures in vitro without tumor-conditioned medium or special substrate. The knob-like structures consisted of acidic and basic glycosaminoglycans arranged in order. Knob-like structures were built from cell extrudates and were responsible for capillary lumen formation in vitro. Transmission electron microscopy confirmed the endothelial nature of the cells which expressed extensive phagolysosomal activity.
源自犬皮下脂肪组织的微血管内皮细胞在体外无需肿瘤条件培养基或特殊基质即可形成瘤状和管状结构。瘤状结构由有序排列的酸性和碱性糖胺聚糖组成。瘤状结构由细胞分泌物构建而成，负责体外毛细血管腔的形成。透射电子显微镜证实了这些细胞的内皮性质，它们表现出广泛的吞噬溶酶体活性。
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