Wen Hui, Wang Xiao-Fang, Huang Yi, Wang Jing-Xing, Yang Guang-Zhong
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Yao Xue Xue Bao. 2010 Jan;45(1):72-6.
Virus inactivation with photochemistry is being suitable for blood or blood products, methylene blue (MB)/light treatment has been used for viral inactivation of cellular blood components. Twelve new phenothiazines derivatives were designed and synthesized, and were used to test viral inactivation and red cell damage preliminary. Results showed that compound YWW-7 has a satisfactory activity, it could be developed as a new viral inactivation agent for blood products.
光化学病毒灭活适用于血液或血液制品,亚甲蓝(MB)/光照处理已用于细胞血液成分的病毒灭活。设计并合成了12种新的吩噻嗪衍生物,并初步用于测试病毒灭活和红细胞损伤情况。结果表明,化合物YWW-7具有令人满意的活性,可开发成为一种新型血液制品病毒灭活剂。