Internal Medicine I and José Carreras Research Center, Department of Dermatology, University of Saarland Medical School, Homburg/Saar, Germany.
J Dermatol. 2011 Jun;38(6):519-23. doi: 10.1111/j.1346-8138.2010.01055.x. Epub 2010 Nov 2.
Psoriasis (Ps) and psoriatic arthritis (PsA) are diseases of unknown origin. However, the receptor activator nuclear factor κ B ligand (RANKL) might play a key role in the pathomechanisms of the disease. Our aim was to study seven single nucleotide polymorphisms (SNP) in the genes encoding for receptor activator nuclear factor κ B (RANK, two SNP), osteoprotegerin (OPG, two SNP) and RANKL (three SNP in patients with Ps and PsA). A case-control study with 156 Ps patients (45 with PsA) and 516 healthy blood donors was conducted to evaluate an association of the SNP with Ps and PsA by genotyping of DNA by polymerase chain reaction. None of the seven SNP showed any differences in the allelic or genotype frequencies between Ps patients and controls. Our study showed no significant association between the SNP in the genes encoding for RANK, OPG and RANKL with susceptibility of disease in Ps and PsA patients.
银屑病（Ps）和银屑病关节炎（PsA）是病因不明的疾病。然而，核因子κ B 受体激活剂配体（RANKL）可能在疾病的发病机制中起关键作用。我们的目的是研究编码核因子κ B 受体激活剂（RANK，两个 SNP）、骨保护素（OPG，两个 SNP）和 RANKL（三个 SNP）的基因中的七个单核苷酸多态性（SNP）在 Ps 和 PsA 患者中的作用。采用病例对照研究，对 156 例银屑病患者（45 例伴银屑病关节炎）和 516 名健康献血者进行 DNA 聚合酶链反应基因分型，评估 SNP 与 Ps 和 PsA 的相关性。在银屑病患者和对照组中，七个 SNP 的等位基因或基因型频率均无差异。我们的研究表明，编码 RANK、OPG 和 RANKL 的基因中的 SNP 与 Ps 和 PsA 患者的疾病易感性之间没有显著关联。
