鞘内给予 γ-氨基丁酸转运蛋白-1 抑制剂 NO-711 对大鼠神经病理性疼痛的镇痛作用。

Analgesic effect of intrathecally γ-aminobutyric acid transporter-1 inhibitor NO-711 administrating on neuropathic pain in rats.

机构信息

Department of Anaesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, PR China.

出版信息

Neurosci Lett. 2011 Apr 20;494(1):6-9. doi: 10.1016/j.neulet.2011.02.028. Epub 2011 Feb 23.

DOI:10.1016/j.neulet.2011.02.028

Abstract

To investigate the analgesic effect of intrathecally administered γ-aminobutyric acid (GABA) transporter-1 inhibitor NO-711 on the sciatic nerve chronic constriction injury (CCI) rats. 5 days after intrathecal catheter placement, neuropathic pain model was established by CCI of sciatic nerve on rats. Withdrawal thresholds for mechanical allodynia and latency for thermal hyperalgesia were measured in all animals. All rats operated upon for CCI displayed decreased withdrawal thresholds for mechanical allodynia and latency for thermal hyperalgesia, which has significant difference compared with sham groups. After intrathecal NO-711 administration, withdrawal thresholds and latency were significantly increased on CCI rats compared with control group after 1 day. The results show that GABA transporter-1 inhibitor could effectively develop analgesic effect in sciatic nerve CCI rats' model.

摘要

目的

研究鞘内给予γ-氨基丁酸（GABA）转运体-1 抑制剂 NO-711 对坐骨神经慢性缩窄性损伤（CCI）大鼠的镇痛作用。鞘内置管 5 天后，通过CCI 大鼠坐骨神经建立神经病理性疼痛模型。所有动物均测量机械性痛觉过敏的缩足阈值和热痛觉过敏的潜伏期。所有接受 CCI 手术的大鼠均表现出机械性痛觉过敏的缩足阈值和热痛觉过敏的潜伏期降低，与假手术组相比有显著差异。鞘内给予 NO-711 后，CCI 大鼠的缩足阈值和潜伏期在给药后 1 天与对照组相比显著增加。结果表明，GABA 转运体-1 抑制剂可有效开发出坐骨神经 CCI 大鼠模型的镇痛作用。