Division of Maternal-Fetal Medicine and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, Campus Box 8064, 4566 Scott Avenue, St Louis, MO 63110, USA.
Clin Perinatol. 2011 Mar;38(1):1-19, v. doi: 10.1016/j.clp.2010.12.007.
Measures of placental dysfunction, including maternal serum analytes and Doppler studies, have been linked to adverse pregnancy outcomes, although the predictive ability of any single one is poor. Improved knowledge of the multifactorial nature of many of the adverse outcomes of pregnancy has sparked interest in the use of multi-parameter models that combine maternal serum analytes with measures of placental structure and blood flow. The combination of various first-trimester and second-trimester analytes and uterine artery Doppler screening show promise as potential screening tools, but large prospective studies are needed to further define their role in clinical practice.
胎盘功能障碍的测量指标,包括母体血清分析物和多普勒研究,与不良妊娠结局有关,尽管任何单一指标的预测能力都较差。对妊娠不良结局的许多多因素性质的认识的提高,激发了人们对使用多参数模型的兴趣,该模型将母体血清分析物与胎盘结构和血流测量相结合。各种早孕期和中孕期分析物与子宫动脉多普勒筛查相结合显示出作为潜在筛查工具的前景,但需要进行大型前瞻性研究来进一步确定它们在临床实践中的作用。