Department of Neurosurgery, Kyungpook National University Hospital 50, Samduk-2-ga, Jung-gu, Daegu 700-721, South Korea.
J Clin Neurosci. 2011 May;18(5):645-8. doi: 10.1016/j.jocn.2010.09.007. Epub 2011 Mar 2.
We conducted a retrospective study of the outcomes of 17 patients who underwent gamma knife radiosurgery (GKRS) for idiopathic trigeminal neuralgia (TN) with a minimum 3-year follow-up. The median interval from GKRS to pain improvement was 4 weeks (range, 1-16 weeks). At the last follow-up, a good treatment outcome was verified in 16 (94.1%) patients (Barrow Neurologic Index pain score, I-IIIb). One patient (5.9%) had treatment failure. On follow up, six patients (35.3%) had a recurrence of pain following some initial relief. Mean time to pain recurrence was 20 months (range, 3-36 months). Four patients (23.5%) experienced treatment-related complications. Three patients reported some degree of post-treatment facial numbness. One patient reported decreased corneal sensation (dry eye syndrome). GKRS is a safe and effective long-term treatment method for TN and should be considered as an alternative option for medically intractable TN.
我们对 17 例接受伽玛刀放射外科手术（GKRS）治疗特发性三叉神经痛（TN）的患者进行了回顾性研究，这些患者的随访时间至少为 3 年。从 GKRS 到疼痛改善的中位间隔时间为 4 周（范围为 1-16 周）。在最后一次随访时，16 例（94.1%）患者的治疗效果良好（Barrow 神经病学指数疼痛评分，I-IIIb）。1 例（5.9%）患者治疗失败。随访中，6 例（35.3%）患者在最初缓解后出现疼痛复发。疼痛复发的平均时间为 20 个月（范围为 3-36 个月）。4 例（23.5%）患者出现与治疗相关的并发症。3 例患者报告术后出现不同程度的面部麻木。1 例患者报告角膜感觉减退（干眼症综合征）。GKRS 是治疗 TN 的一种安全有效的长期治疗方法，对于药物难治性 TN 应考虑作为替代治疗方案。
