Department Internal Medicine, Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Dig Dis Sci. 2011 Sep;56(9):2666-71. doi: 10.1007/s10620-011-1645-7. Epub 2011 Mar 5.
Nurse-administered propofol sedation (NAPS) is now in widespread use. The safety profile of NAPS for routine endoscopic procedures in patients with obstructive sleep apnea (OSA) is unknown.
To compare outcomes of patients with and without OSA undergoing routine endoscopic procedures with NAPS and standard conscious sedation (CS) with benzodiazepines and narcotics.
Retrospective cohort study.
A total of 215 patients were placed in one of four groups: OSA patients undergoing endoscopy with NAPS, OSA patients undergoing endoscopy with standard CS, non-OSA patients undergoing endoscopy with NAPS, and non-OSA patients undergoing endoscopy with standard CS. Procedures were generally accomplished faster with NAPS. There was no statistically significant difference in complication rates or overall outcomes in patients with OSA when compared to non-OSA patients when either NAPS or CS was utilized.
Routine endoscopic procedures using NAPS are safe in patients with documented OSA, with complication rates comparable to when using CS. NAPS helped to decrease procedure times in general.
护士管理的异丙酚镇静（NAPS）现在被广泛使用。对于阻塞性睡眠呼吸暂停（OSA）患者进行常规内镜检查时，NAPS 的安全性尚不清楚。
比较 NAPS 与常规 CS（苯二氮䓬类药物和阿片类药物）治疗 OSA 和非 OSA 患者进行常规内镜检查的结果。
回顾性队列研究。
共有 215 名患者被分为四组之一：接受 NAPS 内镜检查的 OSA 患者、接受标准 CS 内镜检查的 OSA 患者、接受 NAPS 内镜检查的非 OSA 患者和接受标准 CS 内镜检查的非 OSA 患者。与 NAPS 或 CS 相比，OSA 患者的手术时间普遍更快，并发症发生率或总体结果无统计学差异。
对于有记录的 OSA 患者，使用 NAPS 进行常规内镜检查是安全的，并发症发生率与使用 CS 时相当。NAPS 通常有助于缩短手术时间。
