Department of Medicine (Royal Melbourne Hospital), The University of Melbourne, Post Office Royal Melbourne Hospital, Parkville, VIC 3050, Australia.
Trends Parasitol. 2011 Apr;27(4):168-75. doi: 10.1016/j.pt.2011.01.007. Epub 2011 Mar 4.
Placental malaria is hypothesized to lead to placental insufficiency, which causes fetal growth restriction (FGR). In this review, recent discoveries regarding the mechanisms of pathogenesis by which malaria causes FGR are discussed in the wider context of placental function and fetal growth. Placental malaria and associated host responses can induce changes in placental structure and function, affecting pregnancy-associated growth-regulating hormones and predisposing the offspring to hypertension and vascular dysfunction. Risk factors associated with FGR are highlighted, and potential interventions and studies to uncover remaining mechanisms of pathogenesis are proposed. Together, these strategies aim to decrease the burden of FGR associated with malaria in pregnancy.
胎盘疟疾被认为会导致胎盘功能不全，从而导致胎儿生长受限（FGR）。在这篇综述中，我们将更广泛地讨论疟疾导致 FGR 的发病机制，并探讨与胎盘功能和胎儿生长相关的最新发现。胎盘疟疾和相关的宿主反应会引起胎盘结构和功能的变化，影响与妊娠相关的生长调节激素，并使后代易患高血压和血管功能障碍。本文还强调了与 FGR 相关的危险因素，并提出了潜在的干预措施和研究，以揭示发病机制的剩余机制。总之，这些策略旨在减轻与妊娠相关的疟疾引起的 FGR 负担。
