Department of Neurology, Philipps University, Marburg, Germany.
Mov Disord. 2011 Apr;26(5):901-5. doi: 10.1002/mds.23587. Epub 2011 Mar 7.
The objective of this study was to evaluate whether the sensation of thirst differs between patients with progressive supranuclear palsy (PSP), multiple system atrophy with predominant parkinsonism (MSA-P), and Parkinson's disease (PD).
We administered a standardized thirst questionnaire to age-, sex-, and stage-matched patients with probable PSP, PD, and MSA-P and healthy controls (HC), n = 15/group. In an independent cohort (n = 10/group), we provoked thirst by infusing hypertonic NaCl in age-, sex-, and stage-matched patients with PSP, PD, and MSA-P and recorded plasma osmolality and thirst (visual analog scale).
On questioning, 73% of PSP patients reported a reduced sensation of thirst (hypodipsia) compared with previous years (HC, 0%; PD, 7%; MSA-P, 7%; P < .0001). On NaCl infusion, PSP patients reported significantly lower thirst than did PD and MSA-P patients for all times from 20 to 95 minutes (P < .05). The thirst score at 25 minutes discriminated individual PSP patients well from PD and MSA-P patients.
Hypodipsia appears helpful in differentiating PSP from PD and MSA-P.
本研究旨在评估进展性核上性麻痹（PSP）、以帕金森病为主的多系统萎缩（MSA-P）和帕金森病（PD）患者的口渴感是否存在差异。
我们对年龄、性别和分期匹配的可能 PSP、PD 和 MSA-P 患者以及健康对照者（HC）进行了标准化口渴问卷评估，每组 n = 15。在独立队列中（n = 10/组），我们通过输注高渗 NaCl 来诱发口渴，并记录血浆渗透压和口渴感（视觉模拟评分）。
在询问时，73%的 PSP 患者报告口渴感降低（渴感减退），与前几年相比（HC，0%；PD，7%；MSA-P，7%；P <.0001）。在输注 NaCl 时，PSP 患者在 20 至 95 分钟的所有时间点报告的口渴感明显低于 PD 和 MSA-P 患者（P <.05）。25 分钟时的口渴评分能够很好地区分 PSP 患者与 PD 和 MSA-P 患者。
渴感减退有助于将 PSP 与 PD 和 MSA-P 区分开来。
