Breast Cancer Clinic, National Cancer Institute (INCan), Mexico City, Mexico.
Cancer. 2011 Aug 15;117(16):3658-69. doi: 10.1002/cncr.25961. Epub 2011 Mar 8.
Triple-negative breast cancer (TNBC) is defined as breast cancer that is negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. TNBC represents 15% of all invasive breast cancers, but some studies have suggested that its prevalence differs between races. To the authors' knowledge, no previous studies have determined the prevalence of TNBC and its risk factors among Hispanic women.
The authors identified 2074 Hispanic women with breast cancer who attended the National Cancer Institute in Mexico City from 1998 to 2008. All histopathologic and immunohistochemical diagnoses were rereviewed by a breast cancer pathologist. The prevalence of TNBC, its association with clinicopathologic characteristics, and its prognostic impact were determined.
The median patient age at diagnosis (±standard deviation) was 50 ± 12 years. The overall prevalence of TNBC was 23.1%. Younger age (P < .001), premenopausal status (P = .002), increased parity (P = .029), hormonal contraceptive use (P = .04) high histologic grade (P < .001), and advanced disease (P < .001) were associated independently with TNBC. Postmenopausal patients who had a body mass index (BMI) <25 kg/m(2) (P = .027) or <30 kg/m(2) (P < .001) were more likely to have TNBC. In multivariate analysis, patients with TNBC had a higher risk of locoregional recurrence (LRR), lower disease-free survival (DFS) (hazard ratio, 1.62; 95% confidence interval, 1.13-2.32; P = .009), and a lower cancer-specific survival (CSS) rate (hazard ratio, 1.66; 95% confidence interval, 1.20-2.30; P = .002) than patients with non-TNBC.
The median age at diagnosis of Hispanic women with breast cancer was 11 years younger than the average age reported in the United States. The prevalence of TNBC in this study population was higher than that reported in white women with breast cancer. TNBC was associated with a higher risk of LRR and with lower DFS and CSS than those in patients with non-TNBC.
三阴性乳腺癌（TNBC）是指雌激素受体、孕激素受体和人表皮生长因子受体 2 均阴性的乳腺癌。TNBC 占所有浸润性乳腺癌的 15%，但一些研究表明其在不同种族中的患病率不同。据作者所知，之前没有研究确定西班牙裔女性中 TNBC 的患病率及其危险因素。
作者确定了 1998 年至 2008 年期间在墨西哥城国家癌症研究所就诊的 2074 名患有乳腺癌的西班牙裔女性。所有组织病理学和免疫组织化学诊断均由乳腺癌病理学家重新审查。确定了 TNBC 的患病率、与临床病理特征的关系及其对预后的影响。
中位患者年龄（±标准差）为 50 ± 12 岁。TNBC 的总体患病率为 23.1%。年轻（P <.001）、绝经前状态（P =.002）、产次增加（P =.029）、激素避孕药使用（P =.04）、高组织学分级（P <.001）和晚期疾病（P <.001）与 TNBC 独立相关。绝经后 BMI<25 kg/m2（P =.027）或 BMI<30 kg/m2（P <.001）的患者更可能患有 TNBC。多变量分析显示，TNBC 患者局部区域复发（LRR）的风险更高（风险比，1.62；95%置信区间，1.13-2.32；P =.009），无病生存率（DFS）（危险比，1.66；95%置信区间，1.20-2.30；P =.002）和癌症特异性生存率（CSS）率较低。
诊断为乳腺癌的西班牙裔女性的中位年龄比美国报道的平均年龄年轻 11 岁。本研究人群中 TNBC 的患病率高于白人女性。与非 TNBC 患者相比，TNBC 患者 LRR 的风险更高，DFS 和 CSS 更低。
