Automated immunoassay for reliable measurement of sex hormone binding globulin (SHBG).

BACKGROUND

Sex hormone binding globulin (SHBG) is important for the transport and regulation of distribution of sex steroids.

METHODS

The performance of the Architect SHBG automated immunoassay in comparison to radioimmunoassay was evaluated using 62 patient specimens. Furthermore, specimen from 100 healthy individuals were used to establish a preliminary reference interval for this automated assay.

RESULTS

The assay has demonstrated overall good analytical performance and was significantly correlated with the reference method.

CONCLUSIONS

The Architect SHBG assay is a good method for routine measurement of SHBG circulating levels.