ABCB1 基因多态性及其单倍型与抗癫痫药物反应的关联：系统评价和荟萃分析。
Association of ABCB1 gene polymorphisms and their haplotypes with response to antiepileptic drugs: a systematic review and meta-analysis.
机构信息
Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
出版信息
Pharmacogenomics. 2011 May;12(5):713-25. doi: 10.2217/pgs.10.212. Epub 2011 Mar 11.
AIMS
Several studies demonstrated a link between ABCB1 gene variants and the response to treatment in epilepsy, but the results have been inconclusive. Here, we performed the first haplotype meta-analysis to examine the association of haplotypes of ABCB1 common variants with the response to treatment in epilepsy.
MATERIALS & METHODS: We meta-analyzed the studies that evaluated the role of ABCB1 C1236T, G2677T/A and C3435T polymorphisms and their haplotypes in the response to treatment.
RESULTS
Meta-analysis of 23 studies (7067 patients) showed no significant association of ABCB1 alleles, genotypes and haplotypes with the response to treatment in the overall population or in each ethnicity subgroup.
CONCLUSION
Our data suggest that the haplotypes of these loci may not be involved in the response to treatment.
目的
多项研究表明 ABCB1 基因变异与癫痫治疗反应之间存在关联，但结果尚无定论。在此，我们进行了首个单倍型荟萃分析，以研究 ABCB1 常见变异的单倍型与癫痫治疗反应之间的关联。
材料与方法
我们荟萃分析了评估 ABCB1 C1236T、G2677T/A 和 C3435T 多态性及其单倍型在治疗反应中的作用的研究。
结果
对 23 项研究（7067 例患者）的荟萃分析显示，ABCB1 等位基因、基因型和单倍型与总体人群或各亚组人群的治疗反应之间无显著关联。
结论
我们的数据表明，这些位点的单倍型可能不参与治疗反应。
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