Risdon G, Cope J, Bennett M
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, 75235.
Am J Pathol. 1990 Apr;136(4):759-69.
The ingestion of dehydroisoandrosterone (DHA), a naturally occurring steroid, inhibits the development of autoimmunity, neoplasias, and other disorders of rodents. Potential mechanisms of action include (1) the induction of peroxisomal proliferation and (2) the conversion of DHA to androgens. We evaluated the immune system of mice fed DHA. Dietary DHA had no significant effect on antibody responses, cutaneous sensitivity reactions, natural killer activity, or graft-versus-host reactions. However, a decrease in lymphoid organ cellularity and an absence of splenic germinal centers were observed. We assessed progenitor cell activity in irradiated mice by evaluating the repopulation of marrow and lymphoid organs. Dehydroisoandrosterone feeding resulted in an inhibition of lymphopoiesis but not myelopoiesis. Clofibrate, another peroxisomal proliferator, failed to inhibit lymphocyte repopulation after irradiation. Androgen-non-responsive Tfm/Y mice were as susceptible as control mice to the inhibitory effects of DHA on lymphopoiesis. Thus DHA itself may act on lymphoid progenitor cells and/or the microenvironment.
脱氢表雄酮（DHA）是一种天然存在的类固醇，摄入它可抑制啮齿动物自身免疫、肿瘤及其他疾病的发展。其潜在作用机制包括：（1）诱导过氧化物酶体增殖；（2）将DHA转化为雄激素。我们评估了喂食DHA的小鼠的免疫系统。膳食中的DHA对抗体反应、皮肤敏感反应、自然杀伤活性或移植物抗宿主反应均无显著影响。然而，观察到淋巴器官细胞数量减少且脾脏生发中心缺失。我们通过评估骨髓和淋巴器官的再填充情况来评估受辐照小鼠的祖细胞活性。喂食脱氢表雄酮会抑制淋巴细胞生成，但不抑制髓细胞生成。另一种过氧化物酶体增殖剂氯贝丁酯在辐照后未能抑制淋巴细胞再填充。雄激素无反应的Tfm/Y小鼠与对照小鼠一样，对DHA对淋巴细胞生成的抑制作用敏感。因此，DHA本身可能作用于淋巴祖细胞和/或微环境。
