Tiurenkov I N, Samotrueva M A, Kuleshevskaia N R, Berestovitskaia V M, Vasil'eva O S
Eksp Klin Farmakol. 2010 Dec;73(12):25-7.
Experiments on CBA mice with model immunodepression induced by cyclophosphamide showed that phenibut (25 mg/kg) and gammoxin (25 mg/kg) recover both cellular and humoral immunoreactivity and restore lymphoproliferative processes in immunocompetent organs, which is evidence for pronounced immunocorrecting properties of these drugs. A comparative analysis of the immunomodulating activity of phenibut and gammoxin showed that the latter drug predominantly affects the process of immunocompetent cell maturation (growth in mass and cellularity of thymus and spleen--the central immunocompetent organs), while phenibut mostly influences the realization of the final reaction of the primary anti-erythrocyte immune response (significant correction of local infiltration delayed-type hypersensitivity reaction and antibody formation). This difference can be related to the fact that the drugs influence GABA receptors of different types, whereby gammoxin acts on these receptors in immunocompetent organs and phenibut acts on the receptors in lymphocytes.
对环磷酰胺诱导的模型免疫抑制CBA小鼠进行的实验表明，苯乙肼（25毫克/千克）和γ-毒素（25毫克/千克）可恢复细胞免疫和体液免疫反应，并恢复免疫活性器官中的淋巴细胞增殖过程，这证明了这些药物具有显著的免疫纠正特性。对苯乙肼和γ-毒素免疫调节活性的比较分析表明，后一种药物主要影响免疫活性细胞的成熟过程（胸腺和脾脏——中枢免疫活性器官的质量增长和细胞数量增加），而苯乙肼主要影响原发性抗红细胞免疫反应最终反应的实现（显著纠正局部迟发型超敏反应和抗体形成的浸润）。这种差异可能与药物作用于不同类型的GABA受体有关，其中γ-毒素作用于免疫活性器官中的这些受体，而苯乙肼作用于淋巴细胞中的受体。
