Lab. Neurogenómica Cognitiva, Depto. Psicofisiología, Fac. Psicología, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.
Neurosci Lett. 2011 May 2;494(3):202-6. doi: 10.1016/j.neulet.2011.03.013. Epub 2011 Mar 21.
Procedural learning refers to the acquisition of motor skills and the practice that refines their performance. The striatum participates in this learning through a function regulated by endocannabinoid signaling and other systems. This study relates the efficiency in learning a procedural task with the AATn polymorphism of the CNR1 gene, which encodes for the CB1 receptor. The mirror-drawing star task was solved by 99 healthy young subjects in three trials. The sample was divided into high- and low-performance groups based on performance efficiency. AAT12/14 carriers were more frequent in the former group, while there were more AAT12/13 carriers in the latter, which also made more errors/min. Therefore, we characterized two efficiency phenotypes: high- vs. low-performers associated with the two AATn genotypes, AAT12/14 vs. AAT12/13. The findings suggest that AATn polymorphism modifies CNR1 translation, indicating a different modulation of CB1.
程序性学习是指运动技能的习得和通过练习使其表现得到完善。纹状体通过内源性大麻素信号和其他系统调节的功能参与这种学习。本研究将学习程序性任务的效率与编码 CB1 受体的 CNR1 基因的 AATn 多态性联系起来。99 名健康年轻受试者在三次试验中完成了镜像绘图星任务。根据表现效率，将样本分为高绩效组和低绩效组。AAT12/14 携带者在前一组中更为频繁，而在后一组中 AAT12/13 携带者更多，且每分钟错误也更多。因此，我们描述了两种效率表型：高表现者与低表现者与两种 AATn 基因型 AAT12/14 与 AAT12/13 相关。研究结果表明，AATn 多态性改变了 CNR1 的翻译，表明 CB1 的不同调节。
