Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Eur J Intern Med. 2011 Apr;22(2):125-33. doi: 10.1016/j.ejim.2010.12.004. Epub 2011 Jan 5.
Severe sepsis is an infection-induced inflammatory syndrome that can lead to multi-organ dysfunction and continues to be a major cause of morbidity and mortality worldwide. Because numerous cascades are triggered during sepsis, selective blocking of inflammatory mediators may be insufficient to arrest this process, and recent therapeutic approaches have proven controversial. Statins are the most commonly prescribed agents for hypercholesterolaemia and dominate the area of cardiovascular risk reduction. Moreover, these drugs have a variety of actions that are independent of their lipid lowering effect. Such anti-inflammatory, antioxidant, immunomodulatory, and antiapoptotic features have been collectively referred to as pleiotropic effects. By virtue of their pleiotropic effects, statins have also emerged as potentially useful in various critical care areas such as bacteraemia, the early phases of sepsis and septic shock, as well as the management of serious infections. This review outlines current evidence on the use of statins for preventing and treating sepsis.
严重脓毒症是一种感染引起的炎症综合征，可导致多器官功能障碍，仍然是全球发病率和死亡率的主要原因。由于脓毒症过程中会触发许多级联反应，因此选择性阻断炎症介质可能不足以阻止这一过程，最近的治疗方法存在争议。他汀类药物是治疗高胆固醇血症最常用的药物，在降低心血管风险方面占据主导地位。此外，这些药物具有多种独立于其降低血脂作用的作用。这些抗炎、抗氧化、免疫调节和抗凋亡作用统称为多效性。由于其多效性，他汀类药物也已成为各种重症监护领域的潜在有用药物，如菌血症、脓毒症和感染性休克的早期阶段，以及严重感染的治疗。这篇综述概述了目前关于他汀类药物预防和治疗脓毒症的证据。
