Hirata Hirokazu, Arai Yasuyuki, Inano Shojiro, Yoshinaga Noriyoshi, Maruyama Wataru, Fukunaga Akiko, Arima Nobuyoshi
Division of Hematology, Kitano Hospital, Tazuke Kofukai Medical Research Institute.
Rinsho Ketsueki. 2011 Feb;52(2):84-6.
We investigated the hematopoietic status of aplastic anemia with FDG-PET before and after immunosuppressive therapy. FDG-PET showed a patchy uptake pattern before treatment, indicating residual compensatory hypercellular marrow. Three years after successful treatment with ATG plus CsA, the heterogeneity of bone marrow uptake persisted, suggesting that expanded reconstitution of hematopoiesis may require a long time even after the achievement of hematological remission.
我们利用氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）研究了再生障碍性贫血患者在免疫抑制治疗前后的造血状态。FDG-PET显示治疗前呈斑片状摄取模式，提示存在残留的代偿性骨髓细胞增多。在使用抗胸腺细胞球蛋白（ATG）加环孢素A（CsA）成功治疗三年后，骨髓摄取的异质性仍然存在，这表明即使在血液学缓解后，造血功能的广泛重建可能仍需要很长时间。
