Ceilley Roger I
Department of Dermatology, University of Iowa, Carver College of Medicine, West Des Moines, USA.
Skinmed. 2011 Jan-Feb;9(1):15-21.
Formulation development is key to the successful treatment of acne. There has been significant progress over the past few years, but not all developments can be universally applied. An effective topical formulation must provide chemical stability and enhanced penetration of active ingredients at optimal concentrations for efficacy and safety; be cosmetically acceptable; and not add side effects of its own. Both retinoids and fixed combinations containing benzoyl peroxide are commonly used to treat acne, but both have the potential to cause troublesome dose-dependent irritation and dryness. Excipients such as surfactants and alcohol have added to the problem. Two products have recently been introduced where a combination of micronization skills and well-chosen excipients has minimized irritation and dryness without compromising efficacy. Results from two major studies are discussed in this article.
剂型开发是成功治疗痤疮的关键。在过去几年中已经取得了重大进展，但并非所有的进展都能普遍适用。一种有效的局部用剂型必须提供化学稳定性，并在最佳浓度下增强活性成分的渗透，以确保疗效和安全性；在美容上是可接受的；并且不会产生自身的副作用。维甲酸类药物和含有过氧化苯甲酰的固定复方制剂都常用于治疗痤疮，但两者都有可能引起令人烦恼的剂量依赖性刺激和干燥。表面活性剂和酒精等辅料加剧了这一问题。最近推出了两种产品，其中微粉化技术和精心挑选的辅料相结合，在不影响疗效的情况下将刺激和干燥降至最低。本文讨论了两项主要研究的结果。
