Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, USA.
AIDS. 2011 May 15;25(8):1126-8. doi: 10.1097/QAD.0b013e32834671b3.
Neurotrophins control cell survival. Therefore, we examined whether HIV-1 reduces neurotrophin levels. Serum of HIV-positive individuals exhibited lower concentrations of brain-derived neurotrophic factor (BDNF), but not of other neurotrophins, than HIV-negative individuals. In addition, R5 and X4 strains of HIV-1 decreased BDNF expression in T cells. Our results support the hypothesis that reduced levels of BDNF may be a risk factor for T-cell apoptosis and for neurological complications associated with HIV-1 infection.
神经营养因子控制细胞存活。因此，我们研究了 HIV-1 是否降低了神经营养因子的水平。与 HIV 阴性个体相比，HIV 阳性个体的血清中脑源性神经营养因子（BDNF）浓度较低，但其他神经营养因子的浓度没有差异。此外，R5 和 X4 株 HIV-1 降低了 T 细胞中 BDNF 的表达。我们的结果支持这样一种假设，即 BDNF 水平降低可能是 T 细胞凋亡和与 HIV-1 感染相关的神经并发症的一个风险因素。
