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[一种用于慢性腿部溃疡患者疼痛治疗的新型局部应用吗啡凝胶:一项临床研究的初步结果]

[A new topically applied morphine gel for the pain treatment in patients with chronic leg ulcers: first results of a clinical investigation].

作者信息

Huptas L, Rompoti N, Herbig S, Körber A, Klode J, Schadendorf D, Dissemond J

机构信息

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstraße 55, 45122 Essen, Deutschland.

出版信息

Hautarzt. 2011 Apr;62(4):280-6. doi: 10.1007/s00105-011-2141-x.

Abstract

BACKGROUND

The approach to patients with chronic leg ulcers should include not only an accurate diagnosis with appropriate therapy fort he underlying disease, but also the development of effective analgesia. To assess the analgesic effect of topical morphine, we developed a new morphine gel with polihexanide as a preservative for the local pain treatment.

PATIENTS AND METHODS

We have studied 30 patients with painful chronic leg ulcers with an average age of 66 years. The respective pain intensity was assessed 24 hours after application of the morphine hydrogel and objectified with a visual analogue scale (VAS) ranged from 0 to 10.

RESULTS

All investigated patients had a pain intensity of at least 4 points before the topical application of the morphine gel; the average pain intensity was 7.8. After application of the morphine gel, a significant reduction of the average pain intensity was observed, with an average pain intensity of 4.5.

CONCLUSION

These first clinical results with the new morphine gel suggest that at least fort he first 24 hours it combines the advantages of a moist wound healing and a local pain treatment. This new development is certainly a promising therapeutic alternative for pain treatment in patients with chronic leg ulcers.

摘要

背景

对慢性腿部溃疡患者的治疗方法不仅应包括对基础疾病进行准确诊断并给予适当治疗,还应制定有效的镇痛措施。为评估局部用吗啡的镇痛效果,我们研发了一种以聚己缩胍作为防腐剂的新型吗啡凝胶用于局部疼痛治疗。

患者与方法

我们研究了30例慢性腿部溃疡伴疼痛的患者,平均年龄66岁。在应用吗啡水凝胶24小时后评估各自的疼痛强度,并用0至10的视觉模拟量表(VAS)进行客观量化。

结果

所有研究患者在局部应用吗啡凝胶前疼痛强度至少为4分;平均疼痛强度为7.8。应用吗啡凝胶后,观察到平均疼痛强度显著降低,平均疼痛强度为4.5。

结论

新型吗啡凝胶的这些初步临床结果表明,至少在最初24小时内,它兼具湿性伤口愈合和局部疼痛治疗的优点。这一新进展无疑是慢性腿部溃疡患者疼痛治疗的一种有前景的治疗选择。

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