长寿相关线粒体 DNA 5178 C/A 多态性的遗传流行病学研究。
Genetic epidemiological studies of longevity-associated mitochondrial DNA 5178 C/A polymorphism.
机构信息
Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, 181-8611, Tokyo, Japan,
出版信息
Environ Health Prev Med. 2005 Nov;10(6):319-23. doi: 10.1007/BF02898191.
Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism is associated with longevity in the Japanese population, and the Mt5178A genotype may confer antiatherogenic advantages. Individuals with the Mt5178A genotype may be more resistant to adult-onset diseases, such as myocardial infarction, cerebrovascular diseases and type 2 diabetes, than those with the Mt5178C genotype. Moreover, Mt5178 C/A polymorphism has been reported to be associated with blood pressure, serum lipid levels, hematological parameters, intraocular pressure, serum protein fraction levels and serum electrolyte levels in healthy Japanese individuals. Differences in the influence of habitual drinking or habitual smoking on health status between the Mt5178C genotype and the Mt5178A genotype have been reported. The individual modification of drinking habits or smoking habits based on the genotyping of Mt5178 C/A may promote improved health and lead to the establishment of personalized prevention strategies for adult-onset diseases.
线粒体 DNA 5178 胞嘧啶/腺嘌呤（Mt5178 C/A）多态性与日本人的长寿有关，Mt5178A 基因型可能具有抗动脉粥样硬化的优势。与 Mt5178C 基因型相比，Mt5178A 基因型的个体可能对成年发病的疾病（如心肌梗死、脑血管疾病和 2 型糖尿病）更具抵抗力。此外，据报道，Mt5178 C/A 多态性与健康的日本个体的血压、血脂水平、血液学参数、眼内压、血清蛋白分数水平和血清电解质水平有关。有报道称，习惯性饮酒或吸烟对 Mt5178C 基因型和 Mt5178A 基因型个体健康状况的影响存在差异。根据 Mt5178 C/A 的基因分型来改变饮酒习惯或吸烟习惯可能会促进健康状况的改善，并为成年发病的疾病建立个性化的预防策略。
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