CYP2A6 和 CYP2E1 基因多态性与吸烟行为与膀胱癌风险无关。
Genetic polymorphisms ofCYP2A6 andCYP2E1 with tobacco smoking is not associated with risk of urothelial cancer.
机构信息
Department of Urology, Miyazaki Medical College, Miyazaki.
出版信息
Environ Health Prev Med. 2002 Jul;7(3):129-31. doi: 10.1265/ehpm.2002.129.
OBJECTIVES
To elucidate the association between genetic polymorphisms ofCYP2a6 andCYP2E1 and urothelial cancer susceptibility.
METHODS
A total of 137 Japanese patients with urothelial cancer and 217 Japanese healthy controls, frequency-matched for age and gender, were selected. The polymorphisms ofCYP2A6 andCYP2E1 were analyzed by PCR-RFLP, and cigarette smoking histories were obtained through interviews
RESULTS
The frequency ofCYP2A6 homozygote deletion genotype was 2.9% in the patients, compared with 3.2% in the controls (OR=0.84, 95% CI 0.24-2.96). The frequencies ofCYP2E1 C1/c2 andC2/c2 were 27.7% and 4.4% in the patients, compared with 35.5% and 6.0% in the controls (OR=0.68, 95% CI 0.42-1.09, OR=0.67, 95% CI 0.24-1.84, respectively). No statistically significant differences were observed when theCYP2A6 homozygote deletion genotype and theCYP2E1 genotypes were examined relative to smoking status.
CONCLUSIONS
Our data indicate that neither a relationship between genetically impaired nitrosamine metabolism and tobacco-smoking consumption, nor urothelial cancer risk related to theCYP2A6 deletion genotype andCYP2E1 Rsa I genotype was found in Japanese population.
目的
阐明细胞色素 P4502A6（CYP2A6）和细胞色素 P4502E1（CYP2E1）的基因多态性与膀胱癌易感性的关系。
方法
选择了 137 例日本膀胱癌患者和 217 例日本健康对照者，年龄和性别相匹配。通过 PCR-RFLP 分析 CYP2A6 和 CYP2E1 的多态性，并通过访谈获得吸烟史。
结果
患者中 CYP2A6 纯合缺失基因型的频率为 2.9%，而对照组为 3.2%（OR=0.84，95%CI 0.24-2.96）。CYP2E1 C1/c2 和 C2/c2 的频率分别为患者的 27.7%和 4.4%，对照组为 35.5%和 6.0%（OR=0.68，95%CI 0.42-1.09，OR=0.67，95%CI 0.24-1.84）。当根据吸烟状况检查 CYP2A6 纯合缺失基因型和 CYP2E1 基因型时，未观察到统计学差异。
结论
我们的数据表明，在日本人群中，遗传缺陷的亚硝胺代谢与烟草消费之间没有关系，也没有发现 CYP2A6 缺失基因型和 CYP2E1 Rsa I 基因型与膀胱癌风险之间的关系。
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