高危型人乳头瘤病毒与口咽癌患者的颈部淋巴结转移。

High-risk human papillomavirus and cervical lymph node metastasis in patients with oropharyngeal cancer.

机构信息

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, St. Mary's Hospital, The Catholic University of Korea, Seoul.

出版信息

Head Neck. 2012 Jan;34(1):10-4. doi: 10.1002/hed.21697. Epub 2011 Mar 24.

DOI:10.1002/hed.21697

PMID:21438064

Abstract

BACKGROUND

The purpose of this study was to determine the role of high-risk human papillomavirus (HPV) in lymph node metastasis and the depth of invasion in oropharyngeal cancer.

METHODS

The study included patients with 90 oral carcinomas and 66 oropharyngeal carcinomas. High-risk HPV in situ hybridization was performed to detect HPV infection.

RESULTS

The positive rate of high-risk HPV in situ hybridization was 15.4% (24 of 156). There was a significant difference in the fraction of positive high-risk HPV between oral (6.7%) and oropharyngeal (27.3%) cancers (p < .000). Significant correlations were found between positive high-risk HPV and cervical lymph node metastasis, tumor depth of invasion in patients with oropharyngeal cancer (p = .002, p = .016, respectively). There was a statistically significant association between high-risk HPV positivity and the disease-specific survival in patients with oropharyngeal cancer (p = .035).

CONCLUSION

摘要

背景

本研究旨在确定高危型人乳头瘤病毒（HPV）在口咽癌淋巴结转移和浸润深度中的作用。

方法

本研究纳入 90 例口腔癌和 66 例口咽癌患者。采用高危型 HPV 原位杂交法检测 HPV 感染。

结果

高危型 HPV 原位杂交阳性率为 15.4%（24/156）。口腔癌（6.7%）和口咽癌（27.3%）中高危型 HPV 阳性率差异有统计学意义（p<0.000）。高危型 HPV 阳性与口咽癌患者的颈淋巴结转移、肿瘤浸润深度显著相关（p=0.002，p=0.016）。高危型 HPV 阳性与口咽癌患者的疾病特异性生存有统计学关联（p=0.035）。