基于热休克蛋白90抑制作用高效合成一种新型间苯二酚内酯作为抗癌剂
Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition.
作者信息
Lei Xiaoguang, Danishefsky Samuel J
机构信息
Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, New York 10027.
出版信息
Adv Synth Catal. 2008 Aug 4;350(11-12):1677-1681. doi: 10.1002/adsc.200800187.
Abstract
The highly efficient synthesis of a novel heat shock protein 90 (Hsp90)-based anticancer agent, triazole-cycloproparadicicol (5), is described. The key step involves a fragment coupling using "click chemistry." The preliminary biological evaluation of triazole-cycloproparadicicol is also reported.
摘要
本文描述了一种基于新型热休克蛋白90（Hsp90）的抗癌剂三唑-环丙二西醇（5）的高效合成方法。关键步骤涉及使用“点击化学”进行片段偶联。还报道了三唑-环丙二西醇的初步生物学评价。
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