Department of Urology, Clinical Hospital Center Zemun, Vukova 9, 11080 Belgrade, Serbia.
Med Oncol. 2012 Jun;29(2):809-14. doi: 10.1007/s12032-011-9914-z. Epub 2011 Mar 26.
The relationship between plasma levels of total phospholipids (PL) and/or PL fractions and neoplastic diseases are not fully understood. Therefore, the aim of this study was to analyze concentrations and distribution of plasma phospholipids in patients with prostate cancer (PCa) related to the Gleason score, clinical stage and pathologic grade of prostate cancer. We analyzed plasma phospholipids in 57 newly diagnosed, untreated PCa patients and in 43 age-matched healthy male subjects. Significantly lower (P < 0.01) levels of total plasma PL and all PL classes were found in PCa patients when compared with healthy subjects. The relative concentrations of PL fractions were also changed. Further decrease of total PL and PL fractions was found related to an increase of clinical stadium, pathologic grade, and Gleason score, with phosphatidylethanolamine as the most sensitive plasma PL, the level of which significantly decreased even at the first stage of PCa. Our results showed an altered plasma PL profile in PCa patients, which may contribute to monitoring of the disease progression.
血浆总磷脂（PL）和/或 PL 分数与肿瘤性疾病之间的关系尚未完全阐明。因此，本研究旨在分析前列腺癌（PCa）患者的血浆磷脂浓度和分布与 Gleason 评分、临床分期和前列腺癌病理分级的关系。我们分析了 57 例新诊断、未经治疗的 PCa 患者和 43 例年龄匹配的健康男性受试者的血浆磷脂。与健康受试者相比，PCa 患者的总血浆 PL 和所有 PL 类别的水平明显降低（P<0.01）。PL 分数的相对浓度也发生了变化。随着临床分期、病理分级和 Gleason 评分的增加，总 PL 和 PL 分数进一步降低，其中磷脂酰乙醇胺作为最敏感的血浆 PL，其水平甚至在 PCa 的第一阶段就显著降低。我们的结果显示 PCa 患者的血浆 PL 谱发生了改变，这可能有助于监测疾病的进展。
