Divisions of Infectious Diseases & Organ Transplantation, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Am J Transplant. 2011 Jun;11(6):1123-30. doi: 10.1111/j.1600-6143.2011.03493.x. Epub 2011 Mar 28.
Several recent donor-to-recipient disease transmissions have highlighted the importance of this rare complication of solid organ transplantation. The epidemiology of donor-derived disease transmissions in the United States has been described through reports to the Organ Procurement and Transplant Network (OPTN); these reports are reviewed and categorized by the ad hoc Disease Transmission Advisory Committee (DTAC); additional data comes through the published literature. From these reports, it is possible to estimate that donor-derived disease transmission complicates less than 1% of all transplant procedures but when a transmission occurs, significant morbidity and mortality can result. Only through continued presentation of the available data can continuous quality improvements be made. As the epidemiology of donor-derived disease transmission has become better understood, several groups have been working on methods to further mitigate this risk.
近年来，几起因供体向受者传播疾病的事件突显了实体器官移植这一罕见并发症的重要性。美国通过向器官获取与移植网络（OPTN）报告描述了供体源性疾病传播的流行病学情况；这些报告由特设疾病传播咨询委员会（DTAC）进行审查和分类；其他数据来自已发表的文献。根据这些报告，可以估计不到 1%的移植手术会因供体源性疾病传播而复杂化，但当传播发生时，可能会导致严重的发病率和死亡率。只有不断提供现有数据，才能不断改进质量。随着对供体源性疾病传播的流行病学认识的提高，一些小组一直在研究进一步降低这种风险的方法。
