Programa de Pós-graduação em Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.
Neurosci Lett. 2011 May 16;495(2):140-3. doi: 10.1016/j.neulet.2011.03.057. Epub 2011 Mar 31.
The purpose of this research was to investigate the anxiolytic-like effect of diphenyl diselenide [(PhSe)(2)] on the chick social separation-stress behavior. Male chicks (six day-old) received, per oral route, a single administration of (PhSe)(2) at doses of 1, 10 and 50mg/kg. Thirty minutes after treatment, chicks were submitted to the behavioral tests. The behavioral tests: number of separation-induced distress vocalizations and jumps, time of active wakefulness, time of standing/sitting motionless with eyes open, time of standing motionless with eyes closed and time of sleeping posture, during 10 min, were recorded. (PhSe)(2) at doses of 10 and 50mg/kg reduced the number of vocalizations and jumps and the time of active wakefulness and increased the time of standing/sitting motionless with eyes open of chicks. The sleeping posture time was increased in animals treated with (PhSe)(2) at the dose of 50mg/kg. In conclusion, treatment with (PhSe)(2), in a dose dependent-manner, caused anxiolytic-like and sedative effects in chicks.
本研究旨在探讨二苯二硒醚[(PhSe)2]对小鸡社交分离应激行为的抗焦虑样作用。雄性小鸡（6 日龄）经口给予（PhSe）2，剂量分别为 1、10 和 50mg/kg。治疗后 30 分钟，进行行为测试。记录小鸡在 10 分钟内的分离诱导性痛苦发声和跳跃次数、活跃觉醒时间、睁眼站立/静坐不动时间、闭眼站立不动时间和睡眠姿势时间。10 和 50mg/kg 的（PhSe）2 减少了发声和跳跃次数以及活跃觉醒时间，增加了睁眼站立/静坐不动时间。50mg/kg（PhSe）2 处理的动物的睡眠姿势时间增加。总之，（PhSe）2 以剂量依赖的方式在小鸡中产生抗焦虑样和镇静作用。
